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Increased circulating levels of angiotensin-(1-7) in severely ill COVID-19 patients.

Valle Martins, Ana Luiza; da Silva, Filipe Alex; Bolais-Ramos, Lucas; de Oliveira, Gisele Capanema; Ribeiro, Renata Cunha; Pereira, Danilo Augusto Alves; Annoni, Filippo; Diniz, Mirella Monique Lana; Silva, Thuanny Granato Fonseca; Zivianni, Bruna; Cardoso, Alexandre Carvalho; Martins, Juliana Carvalho; Motta-Santos, Daisy; Campagnole-Santos, Maria José; Taccone, Fabio Silvio; Verano-Braga, Thiago; Santos, Robson Augusto Souza.

ERJ Open Res ; 7(3)2021 Jul.

Article in English | MEDLINE | ID: covidwho-1339115

ABSTRACT

This letter reports an unexpected increase of the ACE2 product angiotensin-(1-7) and a parallel decrease of its substrate angiotensin II, suggesting a dysregulation of the renin-angiotensin system towards angiotensin-(1-7) formation in #COVID19 patients https://bit.ly/3xFXuTU.

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